Effect of Naoreqing on endotoxin-induced fever in rabbits
- VernacularTitle:脑热清对内毒素性发热家兔解热作用的实验研究
- Author:
Zhiqin LIU
;
Yufeng JIANG
;
Xiaoli YUE
;
Yongping FAN
;
Ximei WANG
;
Qifu HUANG
- Publication Type:Journal Article
- Keywords:
Endotoxins;
Fever;
Rabbits;
Drugs,Chinese herbal
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the antipyretic effect of Naoreqing(NRQ)oral solution in rabbits with endotoxin-induced fever.METHODS:The ET-induced fever model was established in rabbits.The digital thermometer was used to register rectal temperature.The endothelin content in blood plasma,and tumor necrosis factor-?(TNF?)in blood serum were determined by radioimmunoassay.The activities of tissue-type plasminogen activator(t-PA)and plasminogen activator inhibitor(PAI)in plasma were measured by the assay of chromogenic substrate.At the same time,the pathology of lung,kidney and liver were observed.RESULTS:① NRQ showed obvious antipyretic effect in the rabbits with endotoxin-induced fever(P
