Effects of glutamine and recombinant human growth hormone on intestinal mucosal barrier and proliferating cell nuclear antigen in postoperative portal hypertension patients
- VernacularTitle:Gln和rhGH对门脉高压症术后肠粘膜屏障及增殖细胞核抗原表达的影响
- Author:
Zhaofeng TANG
;
Yunbiao LING
;
Zheng HAO
;
Nan LIN
;
Ruiyun XU
- Publication Type:Journal Article
- Keywords:
Glutamine;
Growth hormone;
Portal hypertension;
Intestinal mucosa barrier;
Proliferating cell nuclear antigen
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate morphologic and functional changes of small intestinal mucosa and proliferating cell nuclear antigen in postoperative portal hypertension patients with single or combined administration of Gln and rhGH.METHODS:Twenty-nine portal hypertension patients with surgical treatment were prospectively randomized to four groups as follows:① Gln group(n=6);② rhGH group(n=8);③ Gln+rhGH group(n=7)and ④ control group(n=8).A standard solution for TPN was given three days after operation for a week.The concentration ratio of urinary lactulose and mannitol(L/M),the villus height and crypt depth and PCNA index of small intestinal mucosa were compared.RESULTS:A week after TPN postoperation,the increased ratios of L/M in Gln+rhGH group were less than those in control group(P0.05).CONCLUSION:This study suggest that Gln together with rhGH reduce the intestinal permeability and protect the mucosa integrality in postoperative portal hypertension patients,but not in single treatment.
