A Short-time Clinical Study on the Efficacy of Homemade Sterilized Powder for Injection of Rifampicin in the Treatment of Pulmonary Tuberculosis
- VernacularTitle:国产注射用利福平灭菌粉末治疗肺结核的近期临床疗效观察
- Author:
Mengqiu GAO
;
Lizhen ZHU
;
Zhizhong YE
;
Songlin YUAN
;
Naihui CHU
;
Liping MA
;
Qingfeng WANG
;
Xiaoguang WU
- Publication Type:Journal Article
- Keywords:
Pulmonary tuberculosis;
Sterilized powder for injection of rifampicin;
Efficacy observation
- From:
China Pharmacy
2005;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study and evaluate the efficacy and safety of homemade sterilized powder for injection of rifampicin(weifunin) in the treatment of pulmonary tuberculosis(PT) and to compared with same import preparation . METHODS:Divide the 121 of bacteriological positive PT patients in the proportion of 1 to 1 with computer automatically into the trial group and the control group used with homemade rifampicin (weifuxin) and import rifampicin(nifu)respectively,the others regimens was same in 2 groups,to evaluate the sputum culture negative conversion rates,X-ray results and adverse drug event etc.after treatment 1 and 2 months . RESULTS: 116 cases were finished ,at the end of 2 month the sputum smear negative conversion rates were 86.21 % and 91.38% (X2=0.780,P=0.377), the sputum culture negative conversion rates were 91.38% and 93.10%(X2=0.120,P=0.729)in the trial group and the control group respectively .The X-ray remarkable effective rates of 2 groups were 82.76% amd 70.69%(X2=2.365,P=0.124)respectively, and the effective rates of the 2 groups were both be 96.55% .The adverse drug event rates were 8.20% and 11.67% respectively, there was on sighificant difference in each indexes .CONCLUSIONS:2 preparation were similar in efficacy ,safety and tolerance.
