Comparison of anti-inflammatory effects between methotrexate and Yangqixue Qufengshi Recipe on mice arthritis induced by collagen II
- VernacularTitle:甲氨喋呤与养气血祛风湿方对II型胶原诱导性关节炎小鼠的抗炎作用研究
- Author:
Fen LI
;
Hong WU
;
Songqing FAN
;
Junwei DENG
;
Jing TIAN
- Publication Type:Journal Article
- Keywords:
Methotrexate;
Drug therapy(TCD);
Arthritis,experimental
- From:
Journal of Chinese Physician
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the anti-inflammatory effects between methotrexate(MTX) and Yangqixue Qufengshi Recipe(YQXQFSR) on mice arthritis induced by collagen II.Methods The model of rheumatoid arthritis was induced by using collagen II in C_(57)BL/6?DBA/1 mice.The rats with arthritis were treated with MTX or YQXQFSR respectively.The indexes such as the onset day of collagen induced arthritis(CIA),the level of CII-reactive antibodies and the pathological scores of CIA were assessed.Results The onset day of CIA and the level of CII-reactive antibodies were not influenced in the treatment of mice arthritis with MTX and YQXQFSR respectively.But MTX could alleviate the damage of cartilage [(1.60?1.51) vs(3.56?1.33) scores,P
