Effect of cilostazol and aspirin on function of platelet assembly rate and change of protein kinase B activity in elderly patients with acute coronary syndrome
- VernacularTitle:西洛他唑及阿斯匹林对老年ACS患者血小板聚集功能及蛋白激酶B活性变化的影响
- Author:
Peiliang LIU
;
Tao JING
;
Zhuo ZHOU
;
Yao CHEN
;
Xuan LI
;
Chunlai SHI
;
Lifeng PEI
- Publication Type:Journal Article
- Keywords:
Cilostazol;
Aspirin;
Acute coronary syndrome;
Platelet assembly rate;
Protein kinase B
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the effect function of platelet(Pt)assemble rate(PLTAR) and the change of protein kinase B(PKB) active by cilostazol (CS)and aspirin (AS)on elderly patients with acute coronary sydrome(ACS). Methods Forty-eight elderly patients with ACS were divided randomly into two groups:CS group (100 mg,n=26),AS group (300 mg,n=22).Twenty-six healthy elderly were into the group of normal control(NC group) . The CS group and AS group were treated by routine anticoagulation and antiplatelet.PLTAR and PKB activity were measured at 10 minutes before treatment and at 7 days after treatment 3.5,6.0,24.0 hours. Results The maximum PLTAR in elderly CS group and AS group was elevated significantly compared with NC group(P
