Induction chemotherapy with low-dose homoharringtonine, cytarabine, and granulocyte colony-stimulating factor priming in patients with advanced myelodysplastic syndrome or post-myelody splastic syndrome acute myeloid leukemia
- VernacularTitle:小剂量高三尖杉酯碱、阿糖胞苷和G-CSF预激诱导治疗高危MDS或MDS转化的AML
- Author:
Jiying SU
;
Xiao LI
;
Chunkang CHANG
;
Lingyun WU
;
Luxi SONG
;
Meiru YANG
;
Quan PU
- Publication Type:Journal Article
- Keywords:
Granulocyte colony-stimulating factor;
Myelodysplastic syndromes;
Acute myeloid leukemia;
Homoharringtonine;
Cytarabine
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
20?10~9/L. This regimen was given for one course for induction, and was followed by conventional chemotherapy as maintenance or consolidation when complete remission(CR) achieved, or succeeding with other treatment when no response could be observed. Results Six patients achieved CR (54.5%) and one achieved partial remission (PR)(9.1%) with one course of treatment. Among 6 of 11 patients with CR, 5 relapsed at 2,3,6,8 and 16 months respectively. Three relapsed patients were retreated with the same protocol but achieved only one partial responses. Nine of the 11 patients had been died and their mean survival (since induction chemotherapy) was 9.2 months. Infectious complications during cytopenia were less serious than conventional chemotherapy withno treatment-related.Conclusion This moderate intensity protocol with G-CSF priming is effective and safe but remissions are of short duration.
