Expression of PTEN and VEGF gene in laryngeal squamous cell carcinoma and their clinical significance
- VernacularTitle:抑癌基因PTEN和血管内皮生长因子在喉癌中的表达及临床意义
- Author:
Zhenxin ZHANG
;
Weirong ZHOU
;
Xiaoxia QIU
;
Peng DA
;
Zhixia WANG
- Publication Type:Journal Article
- Keywords:
Laryngeal Neoplasms;
Carcinoma,Squamous Cell;
Genes,Tumor Suppressor;
Receptors,Vascular Endothelial Growth Factor;
Immunohistochemistry
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the expression of PTEN and VEGF gene in laryngeal squamous cell carcinoma and their clinical significance. METHODS The expression of PTEN and VEGF gene were examined by using immunohistochemical S-P staining method in 10 cases of normal tissues, 20 cases of para-tumor tissues and 60 cases of LSCC. RESULTS The positive rates of PTEN in normal tissues, para-tumor tissues and LSCC were 100.0 %, 95.0 %, and 70.0 % respectively (P＜0.05),and VEGF protein showed positive expression of 20.0 %,50.0 %,73.3% in normal, para-tumor and LSCC tissues with statistical significance(P＜0.05), In LSCC, the expression of PTEN and VEGF was positively correlated with TNM stage, differentiation of tumor, cervical and distant metastasis of lymph node, 3-year survive rate of patients(P＜0.05),No significant association was observed in expression of PTEN and VEGF with tumor location,patient's age and sex(P＞0.05). Spearman correlation analysis revealed that PTEN was negatively correlated with VEGF expression(?=-0.3948, P=0.0018). CONCLUSION The aberrant expression of PTEN and VEGF may play a role in occurrence, progression and metastasis of LSCC.
