Prediction of chemotherapeutic response by determining telomerase activity and serum CA125 expression in patients with ovarian epithelial carcinoma
- VernacularTitle:端粒酶活性联合CA125检测与预测卵巢上皮癌腹腔化疗疗效的关系
- Author:
Yuanyuan SU
;
Jin HUANG
;
Mingfang JI
;
Yuanming LI
;
Ruhong CHEN
;
Xiaoshan LIU
- Publication Type:Journal Article
- Keywords:
Telomerase;
Ovarian neoplasms;
Drug therapy
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate significance of the telomerase activity and serum CA125(cancer antigen 125) expression in the predicting chemotherapeutic response in human ovarian epithelial carcinoma(hOEC).METHODS: The expressive levels of telomerase activity in ascites exfoliative cells or peritoneal washing fluids and the serum CA125 were detected by TRAP-PCR-ELISA and ELISA in 35 hOEC patients.RESULTS:(1) Telomerase activity was detected in 30 out of 35(85.7%) patients(P