Effects of individual antibiotic and immunosuppressive regime on postoperative infection in liver transplant recipients
- VernacularTitle:抗生素和免疫抑制剂的个体化用药对肝移植受体术后感染的影响
- Author:
Zaiping ZHOU
;
Yuanlong YU
;
Zemin HU
;
Hong CHEN
;
Qianxia XIAO
;
Shu JIN
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Immunosuppressive agent;
Antibiotic;
Individual
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effects of individual antibiotic and immunosuppressive regime on postoperative infection in liver transplant recipients. Method There were 31 cases of liver transplantation from March 2001 to May 2005. The recipients received individual antibiotic and immunosuppressive regime based on the drug susceptibility testing and monitoring of blood drug concentration. The incidence and pattern of infection and the mortality in these recipients were analyzed retrospectively. Results There were 15 episodes of infection during recipients' staying in hospital. The common etiologies were Enterobacter cloacae, pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, and Staph. epidermidis. According to the drug sensitive test, targocid/tienam and tazocin were mostly used in antibiotic regime for treatment of postoperative infection. With monitoring of blood concentration, appropriate application of immunosuppressive agents decreased the incidence of infection from 86.7% before 2003 to 48.4% after 2003 (P0.05). Conclusion Individual application of antibiotic and immunosuppressive regime leads to the suppression of infections and other complications in liver transplant recipients.
