Preventive effects of curcumin on status epilepticus induced by lithium chloride-pilocarpine
- VernacularTitle:姜黄素对氯化锂-匹罗卡品诱导癫癎持续状态的预防作用
- Author:
Zhiling HUANG
;
Bo XIAO
;
Liming TAN
;
Shuyu LI
;
Kang WANG
;
Niangui XU
;
Weiping LIU
;
Xiaoyan LONG
- Publication Type:Journal Article
- Keywords:
Status epilepticus/ chemically induced /drug therapy;
Curcumin/pharmacology /therapeutic use;
Lithium chloride/ adverse effects;
Pilocarpine/ adverse effects
- From:
Journal of Chinese Physician
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive effects of curcumin for status epilepticus(SE) induced by lithium chloride-pilocarpine.Methods Totally 45 Sprague-Dawley(SD) rats were randomly divided into three groups: preventive group(n=15),non-preventive group(n=15),and control group(n=15).The latency peroid and incidence of SE were recorded.The surviving neurons were stained by using nissl staining,and the programme death cells were detected by using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL) in hippocampal CA3.Results The SE incidence of preventive group was 66.7%,which was significantly lower than that of non-preventive group(P0.05).Conclusion Pretreatment of curcumin can prevent the SE induced by lithium chloride-pilocarpine and the pretreatment can not protect the neuron.
