Relationship between ulcerative colitis and the levels of nitric oxide and oxygen free radical in serum and intestine mucosal and the treatment of ulcerative colitis with Tanshinone
- VernacularTitle:溃疡性结肠炎与一氧化氮和氧自由基关系及丹参治疗作用研究
- Author:
Jiansheng LIU
;
Yi TIAN
;
Xiaohong ZHANG
;
Li FENG
;
Jing LIU
;
Ji FU
;
Yunlin WU
;
Yaozong YUAN
- Publication Type:Journal Article
- Keywords:
Colitis,ulcerative;
Nitric oxide;
Reactive oxygen species;
Salvia miltiorrhiza/therapeutic use
- From:
Journal of Chinese Physician
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of nitric oxide (NO) and superoxide dismutase(SOD) in the serum and intestine mucosal and the treatment of ulcerative colitis(UC) with Tanshinone.Methods Seventy-nine patients with UC were randomly divided into the treatment group(group A,n=40) and the routine treatment group(group B,n=39).Patients in the group A were given Tanshionon and routine treatment.Patients in group B were given routine treatment.The levels of NO and SOD were measured in all patients before and after the treatment.The clinical symptom,enteroscopy,and hospital day were compared in the patients of the two groups.Twenty normal healthy controls(group C) were involved in the study.Results The NO level in the serum and intestine mucosal was significantly increased and the SOD level was significantly decreased in the patients with UC compared with those of the controls(all P
