Effects of probucol and losartan on cell proliferation after balloon angioplasty in rabbits
- VernacularTitle:普罗布考和氯沙坦对兔血管成形术后细胞增殖的影响
- Author:
Ge XU
;
Shenghua ZHOU
;
Xingsan LI
;
Weiqiang HUANG
;
Hai HUANG
- Publication Type:Journal Article
- Keywords:
Angioplasty;
Probucol;
Losartan;
Cell proliferation
- From:
Journal of Chinese Physician
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of probucol and losartan on cell proliferation after balloon angioplasty in hypercholesterolaemic rabbits.Methods Forty male New Zealand rabbits were randomly divided into high cholesterol diet group,probucol group,losartan group and combined drugs group.The iliac arteries of the rabbits were balloon-injured and the insulin-like growth factor-I receptor(IGF-IR),vascular endothelial growth factor(VEGF),and proliferating cell nuclear antigen(PCNA) were detected by using immunohistochemical method.Results Compared with high cholesterol diet group,the lumen areas were enlarged and the intimal areas were decreased in the probucol group,losartan group and combined drugs group(all P
