Effects of antithyroid drug on oxidative stress in Graves ophthalmopathy patients
- VernacularTitle:Graves眼病抗甲状腺药物治疗后氧化应激的变化
- Author:
Haibing JU
;
Guanglin WANG
;
Dengming HU
;
Zizheng SHU
;
Ziying ZHU
;
Feifei SHEN
- Publication Type:Journal Article
- Keywords:
Graves' disease/therapy;
Antithyroid agents/ therapeutic use;
Oxidative stress
- From:
Journal of Chinese Physician
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of antithyroid drug(ATD) on oxidative stress in Graves disease patients with and without infiltrative ophthalmopathy.Method The levels of superoxide dismutase(SOD),glutathione peroxidase(GPx) and catalase(CAT) in erythrocytes of Graves disease patients(18 with and 20 without infiltrative ophthalmopathy) were measured before and after treatment with ATD.Results Compared with the normal control group,the levels of SOD,GPx and CAT were significantly higher in Graves disease patients with and without infiltrative ophthalmopathy.After euthyroidism was achieved with the treatment of ATD,the levels of SOD,GPx and CAT were normalized in the patients without infiltrative ophthalmopathy,but oxidative stress was still present in the patients with infiltrative ophthalmopathy.Conclusion The oxidative stress is obvious in patients with Graves ophthalmopathy,which suggests that oxidative stress is involved in orbital inflammation.
