Study on the immune modulations of obstructive sleep apnea syndrome
- VernacularTitle:阻塞性睡眠呼吸暂停综合征免疫网络及其与临床的相关性
- Author:
Yan LI
;
Xueping WEN
;
Xuekui CHEN
;
Zhijun YAN
;
Zhonghui WANG
- Publication Type:Journal Article
- Keywords:
Obstructive sleep apnea syndrome;
CD_(58);
Interleukin-6
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of the activity of CR1, the expression of CD_ 58 , the level of soluble interleukin-2R (SIL-2R) and interleukin-6(IL-6) level in serum on obstructive sleep apnea syndrome (OSAS). Methods Select 20 OSAS cases in hospital and 15 healthy controls of the same age. Use flow cytometry and enzyme-linked immunosorbent assay(ELISA) to detect the activity of CR1, the expression of CD_ 58 and the level of SIL-2R, IL-6 in serum. Results (1)The erythrocytes cancer cell rosette(ECR1CaRR)of the OSAS group was lower than that of control group(P0.05). There were significant positive dependability between the level of SIL-2R,IL-6 in serum and SIT90(P0.05). Conclusions There are relations between the level of SIL-2R,IL-6 in serum and the condition of OSAS cases, which can be used to evaluate and define in clinical work,there is a accommodative role between erythrocyte immune function and some cytokines.
