Stability Study and Infrared Spectrum Analysis on Gatifloxacin for Injection in Combination with Aciclovir for Injection
- VernacularTitle:注射用加替沙星与注射用阿昔洛韦配伍的稳定性考察及其红外光谱分析
- Author:
Jizhang YANG
;
Ruiqin LIU
;
Shumin YANG
- Publication Type:Journal Article
- Keywords:
Gatifloxacin;
Aciclovir;
Compatibility;
Stability;
Infrared spectrum
- From:
China Pharmacy
2005;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the compatible stability of gatifloxacin for injection in combination with aciclovir for injection in 0.9% sodium chloride injection or 5% glucose injection.METHODS:Changes in appearance and pH value of gatifloxacin in combination with aciclovir within 8 hours after mixing were observed and determined under room temperature(20?1)℃,respectively,and the precipitates in the mixture underwent infrared spectrum analysis.RESULTS:White flocculent precipitate was noted in the mixture within 1 hour of mixing,which was proved as a new substance by infrared spectrum analysis. CONCLUSIONS:There is incompatibility between gatifloxacin for injection and aciclovir for injection.
