The effect of urinary trypsin inhibitor on the release of inflammatory media in patients undergoing hepatectomy
- VernacularTitle:乌司他丁对肝脏手术后炎症介质释放的影响
- Author:
Xin LU
;
Yilei MAO
;
Xinting SANG
;
Zhiying YANG
;
Shouxian ZHONG
;
Jiefu HUANG
- Publication Type:Journal Article
- Keywords:
Hepatectomy;
Cytokines;
Trypsin inhibitors;
Liver function;
Inflammatory media
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of urinary trypsin inhibitor (UTI) on the release of inflammatory media and oxidation reaction and the mechanism by which UTI protects postoperative liver function following hepatectomy. Methods This was a prospective, randomized, controlled clinical trail, in which cases undergoing hepatectomy were divided into control group (n = 15) and treatment group (n = 15). UTI was administered beginning the day of operation and three days post-op consecutively in the treatment group. Serum CD4, CD8, C-reactive protein(CRP), and gene expressions of IL-1, Il-6, TNF-alpha, iNOS were measured. Results TNF-alpha and iNOS levels significantly decreased in treatment group compared with control 12 hours after surgery (0. 053?0. 02 & 0. 12?0. 04 vs. 0. 084?0. 01 & 0. 21?0. 02, all P
