Effects of acute and chronic morphine dependence and withdrawal on CREB-1 protein expression in rat brain
- VernacularTitle:急性或慢性吗啡依赖和戒断对大鼠脑组织CREB-1表达的影响
- Author:
Qiang FU
;
Xinhua WANG
;
Xiaoyong FU
- Publication Type:Journal Article
- Keywords:
Morphine dependence;
Substance withdrawal syndrome;
DNA binding protein, cyclic AMP responsive;
Brain
- From:
Chinese Journal of Anesthesiology
1996;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05) . The CREB-1 protein expression in cortex and hippocampus was significantly up-regulated while that in nucleus accumbens was significantly down-regulated in chronic morphine dependence and abstinence group (groupⅢandⅣ) as compared with control group. The CREB-1 protein expression in nucleus accumbens in groupⅣwas significantly lower than that in groupⅢ. Conclusion Acute morphine dependence and abstinence do not significantly affect CREB-1 protein expression in the brain. The changes in CREB-1 protein expression are different in different brain regions in chronic morphine dependence and abstinence rats.
