Expression of basic fibroblast growth factor(bFGF),Bax and Bcl-2 in amniochorion of premature rupture of membranes
- VernacularTitle:胎膜早破绒毛膜羊膜bFGF与Bax、Bcl-2的表达
- Author:
Zongjie LU
;
Li JIAN
;
Hongbo QI
- Publication Type:Journal Article
- Keywords:
Fetal membranes,premature rupture;
Fibroblast growth factor 2;
Apoptosis;
(Proto)-oncogene proteins;
Immunohistochemistry
- From:
Chinese Journal of Perinatal Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of basic fibroblast growth factor(bFGF) and proapoptotic gene Bax,Bcl-2 in amniochorion and their relationship with premature rupture of membranes(PROM).Methods Immunohistochemical stain was used to detect the expression of bFGF,Bax and Bcl-2 in amniochorion collected from 30 pregnant women with PROM and 30 normal pregnant women without PROM.Results The expression of bFGF and Bax were located in the plasma of all types of cells including trophoblast,epithelial,mesenchymal and fibroblast,but the expression of Bcl-2 was only observed in the chorionic syncytiotrophoblast;the positive average integral calculus oculus dehtor of bFGF in the PROM group was significantly lower than that of the normal group(0.051?0.012 vs 0.098?0.027,P0.05).Negative correlation was found between the bFGF and Bax expression in the PROM group(r=-0.616,P0.05). Conclusions The reduced expressions of bFGF and excessive apoptosis in the amnio-chorion play an important role in PROM.
