Preparation and in Vitro Drug Release Characteristics of Aspirin Gastric Floating Capsule
- VernacularTitle:小剂量阿司匹林胃漂浮胶囊的制备及其体外释药特征的研究
- Author:
Weiguang SUN
;
Yi CHENG
- Publication Type:Journal Article
- Keywords:
Aspirin;
Hydroxypropyl methylcellulose;
Carbopol;
Gastric floating capsule;
Drug release characteristics
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare aspirin gastric floating capsule and to study its in vitro drug-release characteristics.METHODS:Aspirin gastric floating capsule was prepared with aspirin as model drug,and with hydroxypropyl methylcellulose(HPMC)under different viscosity and different quantity and carbopol as main excipients.The release rate of the capsules was determined.RESULTS:When the optimal ratio between HPMC K4M and HPMC K15M was3to1,then the in vitro drug release of aspirin gastric floating capsule within0h～10h conformed to apparent zero-order kinetics with rate constant Kr at10.3%/h and release parameter at0.6173.CONCLUSIONS:The prepared capsule has a marked slow-release effect,the quantity and the viscosity of HPMC were the main factors affecting the release rate of gastric floating capsule,the in vitro drug release characteristics were associated with the joint action of bulk erosion and drug diffusion.
