Protective effects of taurine on liver and kidney injury induced by intestinal ischemia-reperfusion in rats
- VernacularTitle:牛磺酸对大鼠小肠缺血再灌注后肝、肾损伤的保护作用
- Author:
Liquan TONG
;
Haiquan QIAO
;
Guangping SONG
;
Yuli WANG
;
Fanqiang MENG
;
Baoguo ZHOU
;
Xueying SUN
- Publication Type:Journal Article
- Keywords:
Reperfusion/prev;
Taurine/ther use;
Liver/plysiopathol;
Kidney/physiopathol;
Intestinal Ischemia
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of taurine on liver and kidney injury induced by intestinal ischemia-reperfusion(I/R) in rats.Methods Male Wistar rats were randomly assigned into Sham,I/R,and taurine groups.Thirty min before operation,2% taurine(200 mg/kg) was injected via dorsal vein of the rat′s penis.Intestinal ischemia-reperfusion was produced by occlusion of superior mesenteric artery for one hour later,then the blood flow was restored by removing the clamps.Blood samples were taken from rats in I/R and taurine groups at 1.5,3,6 and 12h after reperfusion,and the serum levels of ALT,AST,BUN and Cr were measured to evaluate the functions of liver and kidney.Tissues from livers and kidneys were cryostated and stained with hematoxylin and eosin to observe changes in histological pathology.TUNEL was also performed to examine apoptotic cells and the average light density levels were measured.Results The serum levels of ALT,AST,BUN and Cr in I/R group were significantly higher than those in Sham group(P
