Effect of angiopoietin2,hypoxia inducible factor-1? and vascular endothelial growth factor on angiogenesis in human hepatocellular carcinoma
- VernacularTitle:Ang2,HIF-1?及VEGF对肝癌血管形成的影响
- Author:
Yufeng YUAN
;
Zhisu LIU
;
Yueming HE
;
Qun QIAN
;
Bicheng WANG
;
Congqing JIANG
;
Yunhua WU
;
Zhongli AI
- Publication Type:Journal Article
- Keywords:
Hapatocellular Cancer/pathol;
Angiopoietin;
Hypoxia Inducible Factor;
Vascular Growth Foctor
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between hypoxia inducible factor-1?、angiopoietin2 and vascular endothelial growth factor and angiogenesis in hepatocellular carcinoma(HCC).Methods The(expression) of hypoxia inducible factor-1?、angiopoietin2 and vascular endothelial growth factor mRNA was(detected) in 52 HCC surgical specimens.And microvessel density(MVD) in tissue specimens of patients with coexpression of the parameters was examined.Results Of the 52 surgical specimens,36 cases had over(expression) of HIF-?、angiopoietin and VEGF protein,and coexpression of HIF-? and angiopoietin and VEGF mRNA in 38 of 52 cases.The expression of HIF-?、angiopoietin was related with the expression of VEGF(r_1= 0.783,P
