Expression of telomere regulating factor tankyrase in gastric adenocarcinoma
- VernacularTitle:端粒调控因子tankyrase在胃腺癌中的表达
- Author:
Lidan TANG
;
He HUANG
;
Jie SUN
;
Yichun WU
;
Xiaoyu LAI
;
Yuanyuan ZHU
;
Jianping LAN
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Tankyrase;
Telomere
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To detect the expression level of telomere regulating factor tankyrase and its clinical significance in the origin and development of gastric adenocarcinoma. METHODS: Quantitative Real-time PCR was used to measure the expression of tankyrase mRNA in cancerous and normal adjacent tissues from 16 patients with gastric adenocarcinoma. Immunohistochemistry was used to detect tankyrase protein expressions in 37 gastric adenocarcinoma samples and 13 normal controls. RESULTS: The expression of tankyrase mRNA in gastric adenocarcinoma [median 1.44?10~ -2, range (3.88?10~ -5)-0.4847] was significantly higher than that in normal adjacent mucosa [median 1.0134?10~ -2, range 0-(4.933?10~ -2)] (P
