5’-GpG islands of p15 gene hypermethlation in non-Hodgkin’s lymphomas
- VernacularTitle:非何杰金淋巴瘤p15基因操纵区5’-CpG岛的甲基化的研究
- Author:
Tao ZHOU
;
Hongtao FAN
;
Ning ZHANG
;
Xingjing LIU
;
Baochun HU
;
Qiuye GUO
;
Xiuzhi GUO
- Publication Type:Journal Article
- Keywords:
Gene, p15;
Methylation;
Lymphoma, non-Hodgkin
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To illustrate the expression of hypermethylation p15 gene in 53 non-Hodgkin’s lymphoma (NHL). METHODS: The methylation of p15 gene in 53 cases of non-Hodgkin’s lymphoma was detected by using methylation-specific PCR (MSP) technique. RESULTS: 18.9% (10/53) in NHL were methylation in p15 gene. p15 gene was frequently in high malignant NHL patients (27.3%) compared with in low malignant patients (0%). CONCLUSION: The result suggested that the hypermethylation of p15 may play an important role in non-Hodgkin’s lymphoma.
