Protective effects of tongxinluo, carvedilol and valsartan on microvascular endothelial function and integrity after late reperfused AMI in rabbits
- VernacularTitle:通心络、卡维地洛、缬沙坦对兔急性心肌梗死晚期再灌注微血管内皮功能及完整性保护作用的对比
- Author:
Yuejin YANG
;
Jian ZHANG
;
Yongjian WU
;
Yida TANG
;
Xi CHEN
;
Yingmao RUAN
;
Shijie YOU
;
Kunshen LIU
;
Jilin CHEN
;
Runlin GAO
;
Zaijia CHEN
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Reperfusion injury;
Endothelium, vascular;
Tongxinluo;
Carvedilol;
Valsartan
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To compare the protective effects of tongxinluo, a Chinese medicine, and carvedilol and valsartan on myocardium microvascular endothelial function and integrity after late reperfusion of acute myocardial infarction (AMI) in rabbits. METHODS: Forty-eight rabbits were randomly assigned to the following groups: (1) sham operated rabbits; (2) ischemia-reperfusion (I-R) controls; (3) tongxinluo (1.0 g?kg~ -1?d~ -1); (4) carvedilol (5 mg?kg~ -1?d~ -1); (5) valsartan (10 mg?kg~ -1?d~ -1) and (6) ticlopidine + aspirine (30 and 20 mg?kg~ -1?d~ -1, respectively) groups. After 3 d of drug treatment, the left coronary artery in the rabbit was ligated for 2 h and loosed subsequently for another 2 h. The serum levels of nitric oxide (NO_2~-/NO_3~-) and endothelin (ET) at baseline before AMI, 2 h after both AMI and reperfusion were examined. Also, the number of circulating endothelial cells (CEC), MI size and percentage myocardium focal bleeding incidence were determined 2 h after reperfusion. RESULTS: (1) The baseline level of NO_2~-/NO_3~- was significantly higher in tongxinluo group than that in other groups (all P
