Expression of proteins in p53(Mdm2-p53-p21~(WAF/CIP1)) pathway in thyroid carcinoma
- VernacularTitle:甲状腺癌p53调节基因Mdm2以及p21~(WAF/CIP1)蛋白的表达
- Author:
Shuwen PENG
;
Jiannan HUANG
;
Xiqing JI
;
Xinhua SHENG
;
Jinggang TANG
;
Yinxi ZHANG
- Publication Type:Journal Article
- Keywords:
Thyroid Neoplasms;
Microchip Analytical Procedures;
Oncogene;
Protein p53
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the significance of expression of p53, Mdm2 and p21WAF/ CIP1 proteins and their relationships. METHODS Pathological specimens from thyroid carcinoma, adjacent non-tumor thyroid tissues and thyroid benign lesions were examined for p53, Mdm2 and p21WAF/CIP1 proteins by tissue microarray technique and immunohistochemistry method. RESULTS The positive expression rate of p53, Mdm2 and p21WAF/CIP1 in thyroid carcinoma was 50.6 %(37/73), 63.0 %(47/73) and 38.4 %(28/73) respectively. The expression of p53 and Mdm2 increased(P
