The changes of GABA and Glu in rat inferior colliculus after unilateral cochlear ablation
- VernacularTitle:大鼠单侧耳蜗损毁后下丘r氨基丁酸和谷氨酸变化
- Author:
Qinying WANG
;
Qingquan HUA
;
Shenqing WANG
;
Bokui XIAO
;
Hua LIAO
- Publication Type:Journal Article
- Keywords:
gamma-Aminobutyric Acid;
Inferior Collic ulus;
DNA,Recombinant
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the changes of GABA and Glu in rat inferior colliculus following unilateral cochlear ablation and explore the function and significance of GABA and Glu in reorganization of auditory center after deafferentation. METHODS Twenty-five Sprangue Dawley (SD) rats were divided randomly into 5 groups. The content of GABA and Glu were measured by 835-50 type Amino Acid Automatism Analyzer and compared at 1 week, 2 week and 1 month after unilateral cochlear ablation respectively. RESULTS Compared with sham operated groups, the content levels of GABA decreased (from 78.00?7.50 to 51.65?10.36, about decreasing 33.6 %)1 week after unilateral cochlear ablation and there was a significant difference in GABA levels between 2 groups(P0.05). CONCLUSION The dynamic change of GABA and Glu in rat inferior colliculus reflected the neuronal activity, which implied both GABA and Glu may play an important role in reorganization of auditory center after unilateral cochlea ablation.
