Inhibitory Action of Salidrose on Hepatic Fibrosis
- VernacularTitle:红景天苷抗肝纤维化的实验研究
- Author:
Yi ZHANG
- Publication Type:Journal Article
- Keywords:
Salidrose;
Hepatic fibrosis model;
Rats
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the inhibitory action of salidrose on hepatic fibrosis of rats.METHODS:CCl 4 -induced hepatic fibrosis rat(n=55)model was built up,then were administrated low,median and high dose of salidrose positive control malotilate,and compared with normal group(n=10),the pathohistological changes were observed after6wk under light microscope and hepatic fibrosis degree was monitored before and after treatment by determining levels of ALT,AST,NO,HA and LN in serum and Hyp and MDA in liver tissue.RESULTS:Salidrose significantly reduced the elevated levels of ALT,AST,NO,HA,LN in serum and the exorbitant Hyp and MDA in liver tissue.Histopathologic examination also showed its significant amelioration effect on experimental liver fibrosis.CONCLUSION:Salidrose has inhibitory action on experimental liver fibrosis to some extent.
