Optimization of the Preparation Techniques of Floxuridinyl Diacetate Solid Lipid Nanoparticles by Orthogonal Test
- VernacularTitle:正交试验法优选氟尿苷二乙酸酯固体脂质纳米粒制备工艺
- Author:
Jiafang LIAN
;
Sanqi ZHANG
;
Yi GU
;
Kunquan FANG
;
Miaomiao XI
;
Li WANG
- Publication Type:Journal Article
- Keywords:
Orthogonal design;
Floxuridinyl diacetate;
Solid lipid nanoparticles;
Entrapment efficiency;
Drug loading dosage
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the preparation techniques for floxuridinyl diacetate solid lipid nanoparticles(FUDRA-SLN).METHODS:The FUDRA-SLN was prepared by film-ultrasound dispersion method with soybean phos?pholipids as carrier,and the preparation techniques were optimized by means of an orthogonal test design with entrapment ef?ficiency and appearance as indexes of investigation.RESULTS:The FUDRA-SLN prepared in the optimized techniques was even and regular in appearances,with particle diameter at(215?83)nm,entrapment efficiency at98.27%and drug loading dosage at8.20%.CONCLUSIONS:FUDRA-SLN prepared by the optimized film-ultrasound dispersion method has a high entrapment efficiency and high drug loading dosage,and this method is suitable for the laboratory preparation.
