Preparation of Nystatin Buccal Adhesive Tablets and Adhesiveness Study
- VernacularTitle:制霉菌素口腔粘附片的研制及粘附性考察
- Author:
Yang ZOU
;
Hua HUANG
- Publication Type:Journal Article
- Keywords:
Nystatin;
Buccal adhesive tablets;
Adhesiveness
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare nystatin buccal adhesive tablets and to study their properties of bioadhesion.METHODS:Nystatin buccal adhesive tablets of different formula matching ratio were prepared with carbomer(CP)and hy?droxy-propyl methyl cellulose(HPMC)as adhesive material and slow-release framework,and the adhesive power,duration of adhesion,swelling percentage and surface pH data of which were determined.RESULTS:There were great differences regarding bioadhesive properties among the adhesive tablets that of different formula matching ratio,the adhesive tablets that prepared in a formula matching ratio of1:1between CP to HPMC were of the best adhesiveness outcome.CONCLUSIONS:The buccal adhesive tablets were prepared successfully,and which can be used for the further study both in vivo and in vitro.
