Preparation and Per Cutem Permeability Test of Ketoprofen Poultice
- VernacularTitle:酮洛芬巴布剂的制备及其经皮体外渗透试验
- Author:
Xiaoxia CHE
;
Zhixia XI
- Publication Type:Journal Article
- Keywords:
Ketoprofen;
Poultice;
Orthogonal test;
Adhesive stress;
Steady permeation flux
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the matrix formulation of ketoprofen cataplasm and to investigate its influencing factors.METHODS:Orthogonal design was used to design formulations,adhesive stress was tested with the tension meter and the per cutem permeability in vitro was studied using the franz diffusion cell.RESULTS:The optimal poultice was acquired with adhesive stress at40N and steady permeation flux at9.72?g/(cm 2 ?h).CONCLUSION:The established preparation technique of poultice is stable and feasible,and its leading influencing factors are adhesive stress and transdermal effects.
