Pharmacokinetics of Indapamide by Oral in Human Body
- VernacularTitle:口服吲达帕胺片人体药动学研究
- Author:
Jianguo ZHANG
;
Zuoji LI
- Publication Type:Journal Article
- Keywords:
Indapamide;
HPLC;
Pharmacokinetics;
Blood concentration
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for the determination of serum indapamide concentration.METHOD:10healthy male volunteers were assigned to receive7.5mg indapamide capsule on empty stomach with time-concentration de?termined by HPLC,and the pharmacokinetics parameters were accounted.RESULTS:C max was(0.212?0.167)mg/L,t max was(2.14?0.59)h,t 1/2 was(19.69?0.75)h,AUC 0～72 was(3.636?0.503)(mg?L)/h and AUC 0～∝ was(3.937?0.518)(mg?L)/h.CONCLUSION:The established method can be used for the clinical analysis on the use of indapamide and its pharmacokinetics study.
