Stability and Expiration Date Prediction of Betamethasone Cream
- VernacularTitle:倍他米松乳膏的稳定性及有效期预测
- Author:
Meiying QIAN
;
Liyan MIAO
;
Jian SHI
;
Jinhua WANG
;
Hua ZHANG
- Publication Type:Journal Article
- Keywords:
HPLC;
Betamethasone cream;
Initial mean velocity method;
Content;
Stability;
Expiration date
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the stability and to predicate the expiration date of betamethasone cream.METHODS:The HPLC method was used to determination the content of betamethasone,the stability test of cream was done by initial mean velocity method and strong light exposure experiment,respectively.RESULTS:The linear concentration range for betametha?sone cream was0.25～8?g/ml(r=0.9991),the average recovery rate was98.56%,RSD=0.78%;The content was highly correlated to temperature,whereas on which the light exposure did little effect.CONCLUSIONS:Betamethasone cream should be stored under room temperature and in a cool place,it is predicted that the expiration date of betamethasone cream is1year.
