The Relationship of Serum Levels of Adiponectin and Tumor Necrosis Factor-? in the First-degree Family Relatives of Patients with Type 2 Diabetic
- VernacularTitle:2型糖尿病家系一级亲属血清脂联素、肿瘤坏死因子-?与胰岛素抵抗的相关性研究
- Author:
Yan ZHOU
;
Ke SU
;
Yan LONG
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes;
First-degree relatives;
Adiponectin;
Tumor necrosis factor-?;
Insulin resistance
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of serum levels of adiponectin and tumor necrosis factor-?in the first-degree family relatives of patients with type 2 diabetic mellitus and the relationship of adiponectin and TNF-?with insulin resistance.Methods 45 families with type 2 diabetes were recruited.The observation group comprised 83 first-degree relatives who were with normal glucose tolerance(NGT).The normal control group comprised 76 NGT spouses of the probands and his/her siblings.The levels of fasting blood glucose,insulin,proinsulin,lipid,adiponectin and TNF-? were measured among two groups.Insulin resistance was calculated using the homeostasis assessment(HOMA).Results The levels of TG,fasting insulin(FINS),fasting proinsulin(FPI),TNF-? and HOMA-IR in first-degree relatives were significantly higher(P
