The Analysis of High Sensitive C-reactive Protein and Microvascular Complications and Its Relative Factors in Patients with Type2 Diabetes Mellitus
- VernacularTitle:2型糖尿病患者高敏C-反应蛋白与微血管并发症及相关因素的分析
- Author:
Liping HAN
;
Demin YU
;
Yun XIE
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,Non-insulin-dependent;
High sensitive C-reactive protein;
Microvascular complications;
Sub-clinical inflammation
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels of serum high sensitive C-reactive protein(hs-CRP) in different stages of diabetic nephropathy and the relationship between hs-CRP and relative metabolic indexes.Methods According to their urinary albumin excretion rate(UAER),164 patients with type2 diabetes mellitus were divided into three groups: 51 patients with normal UAER,59 patients with microalbuminuria and 54 patients with clinical proteinuria.The concentration of hs-CRP,relative clinical biochemical profiles and the body height,weigh,systolic & diastolic blood pressure were measured and analyzed.Correlation analysis was also done between hs-CRP and other relative indexes.Result The levels of hs-CRP were increased with increment of UAER.Pearson correlation analysis and stepwise linear regression indicated that hs-CRP was positive correlated with duration,triglyceride(TG),BMI,MAP,HOMA-IR,fibrinogen(FIB),UAER,serum creatinine(Cr),HbA1C,but negative correlated with high-density lipoprotein(HDL-C) and HOMA-B.The levels of hs-CRP in female were higher than those in male.Conclusion High level of serum hs-CRP concentration maybe a risk factor for the onset of type2 diabetes mellitus and diabetic nephropathy.
