Regulatory effects of JNK transduction on interleukin-1?-induced proliferation in rat hepatic stellate cells
- VernacularTitle:JNK信号转导通路对白细胞介素-1?促肝星状细胞增殖的调控作用
- Author:
Yaping ZHANG
;
Xixian YAO
;
Xia ZHAO
- Publication Type:Journal Article
- Keywords:
Signal transduction;
Interleukin-1;
Hepatic stellate cells;
Cells proliferation
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the action of JNK in stimulating proliferation in rat hepatic stellate cells (HSCs) induced by interleukin-1?. METHODS: Activation of JNK was detected with Western blotting, while the proliferation of HSCs induced by interleukin-1? and the effect of JNK specific blockade SP600125 were measured with cell counting kit-8. RESULTS: Interleukin-1? up-regulated proliferation in rat HSCs, which was obviously inhibited by SP600125, compared with control group (without SP600125 treatment) (1.560?0.110), the decrease was significant (1.427?0.113, P
