Dual effects of antithrombin Ⅲ on inflammatory factor and blood coagulatory factor in rats with hemorrhagic shock
- VernacularTitle:抗凝血酶Ⅲ对失血性休克大鼠凝血、炎症反应的双重调节作用
- Author:
Yanjie ZHANG
;
Jingye PAN
;
Mingshan WANG
- Publication Type:Journal Article
- Keywords:
Antithrombin III;
Shock;
Inflammation
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the changes of inflammatory factors and blood coagulatory factors and effects of antithrombin Ⅲ (ATⅢ) on activated inflammatory factors and blood coagulatory factors in rats with hemorrhagic shock. METHODS: The rat model of hemorrhagic shock was set up. 40 SD rats were randomized into four groups: sham operation, shock, routine dose ATⅢ and high dose ATⅢ groups, each group was composed of 10 SD rats. Shock group was administered common resuscitation fluid, routine dose ATⅢ group was administered ATⅢ 20 U/kg, high dose ATⅢ group was administered ATⅢ 100 U/kg everyday for successive three days. Plasma NF-?B, 6-Keto-prostaglandinF1?, E-selectin, sICAM-1, thrombin-ATⅢ complexes, thrombinogen fragment F1+2 (PF F1+2), D-dimer and TMD levels were detected. RESULTS: Plasma NF-?B, sICAM-1, E -selectin levels were significantly lower in high dose ATⅢ group than those in shock group and routine dose ATⅢ group (P
