Relationship between the children interleukin 1?(-511) gene polymorphisms and susceptibility to febrile seizures
- VernacularTitle:热性惊厥儿童白细胞介素-1?(-511)基因多态性分析
- Author:
Shuhua LI
;
Chaofeng HU
;
Techang LIU
- Publication Type:Journal Article
- Keywords:
Seizures, febrile;
Cenetics;
Gene polymorphism;
Interleukin-1;
Child
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate association between children interleukin 1?(-511) gene polymorphisms and susceptibility to febrile seizures. METHODS: Children were devided into two groups: those with febrile seizures (FS) and healthy control, FS group was also devided into family history group and non-family history group. Single nucleotide polymorphisms of IL-1?-511 gene in promoters were detected by PCR-RFLP among these groups. RESULTS: Genotypes for IL-1? promoter -511 (T-T, T-C, C-C) in total febrile seizures and healthy controls were not significantly differen. Genotype IL-1?-511(T-T) in family history patients is 46.2% ,which is much higher than those in non-family history group (10.3%) and healthy control group (5.7%). The genotype proportions for IL-1? promoter-511 in family history group were markedly different from those in non-family history patient group and control group (P
