Effect of integrin ?2 on adhesion of neuroblastoma cells to collagen
- VernacularTitle:整合素?2对神经母细胞瘤细胞粘附于胶原蛋白的调节作用
- Author:
Feiqiu WEN
;
Zhiping LIU
;
Yixin CHEN
;
Shayan WANG
;
Feng LIU
- Publication Type:Journal Article
- Keywords:
Neuroblastoma;
Adhesions;
Integrins;
Collagen
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of integrin ?2 on adhesion of SK-N-SH neuroblastoma cells to collagen. METHODS: Adhesion of the SK-N-SH cells to immobilized collagen was tested with various concentration of Mg~ 2+ , Ca~ 2+ and with 10 ?g/L anti-?2 monoclonal antibody (mAb) 6F1. A_ 570 was detected as adhesion cell numbers. RESULTS: Mg~ 2+ -dependent adhesion of SK-N-SH cells to type I collagen was increased significantly, with peak adhesion at concentration of 1 mmol/L Mg~ 2+ . A_ 570 with or without Mg~ 2+ was 0.59?0.03 and 0.25?0.01 respectively (P
