Toll-like receptor 2 and 4 gene expression in acute injury liver tissue of acute hemorrhagic necrotizing pancreatitis rats and the efficacy of intervention with Chloroquine
- VernacularTitle:急性出血坏死性胰腺炎肝损伤中TLR2/4mRNA的表达及氯喹的干预效应
- Author:
Peng HUANG
;
Heshui WU
;
Lei ZHANG
;
Chunyou WANG
- Publication Type:Journal Article
- Keywords:
Pancreatitis,Acute Necrotizing;
Hepatocytes/metab;
Chloroquine/ther use;
TLR
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of Toll-like receptor 2 and 4 gene expression in acute injury liver tissue of acute hemorrhagic necrotizing pancreatitis(AHNP) rats and the efficacy of intervention with chloroquine(CQ).Methods Seventy SD male rats were randomly divided into Sham-operated group(n=10),AHNP group(n=30) and Chloroquine-treated group(n=30).Levels of serum amylase,ALT,AST,NO and TNF-? were detected.TLR2/4mRNA expression in the livers were measured by RT-PCR.Results Comparing to shamoperated group,TLR2/4mRNA was markedly increased at 3 hours in liver(tissues) in AHNP group,peaking at 6～12 hours(P
