The effect of hyperbaric oxygen treatment on plasma endotoxin,sCD14 and plasma endotoxin inactivation capacity in acute necrotizing pancreatitis in rats
- VernacularTitle:高压氧对大鼠急性坏死性胰腺炎血内毒素、sCD14及血浆灭活内毒素能力的影响
- Author:
Danian TANG
;
Yongguo LI
;
Mingwei ZHU
;
Junming WEI
;
Bei WU
;
Xiuwen HE
- Publication Type:Journal Article
- Keywords:
Pancreatitis/ther;
Hyperbaric Oxygen;
Endotoxin/blood;
SCD14/blood
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of hyperbaric oxygen(HBO) treatment on plasma endotoxin,sCD14 and plasma endotoxin inactivation capacity(EIC) in acute necrotizing pancreatitis(ANP) in rats and its possible mechanism.Methods SD rats were randomly divided into control group,sham operation group,ANP group and ANP+HBO group.Rat ANP models were made by retrograde injection of 3.5% sodium(taurocholate)(2.5mL/kg) into the pancreatic duct.Thirty minues after models had been made,ANP+HBO group was treated by hyperbaric oxygen for 2h.At 3h,6h,and 10h after establishment of rat models,the plasma endotoxin,sCD14,EIC,TXB_2 and 6-K-PGF_(1a) leves were determined in each group.Results At 3h and 6 h after rat models were established,the levels of endotoxin,sCD14,and TXB_2 in ANP+HBO group were significantly lower than those in ANP group(P
