Polymorphisms of the thymidylate synthase gene promoter in bladder transitional cell carcinoma and its relationship with invasiveness
- VernacularTitle:胸苷酸合酶启动基因与膀胱移行细胞癌侵袭性关系的实验研究
- Author:
Kaihuan YU
;
Xiaobing ZHANG
- Publication Type:Journal Article
- Keywords:
Thymidylate synthase;
Bladder neoplasms;
Neoplasm invasiveness
- From:
Journal of Chinese Physician
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between polymorphisms in the thymidylate synthase(TS) promoter enhancer region and invasion of bladder transitional cell carcinoma(BTCC).Methods The TS gene promoter and TS protein expression were detected by PCR and immunohistochemical Streptavidin-Peroxidase staining method respectively in 87 cases of BTCC and the immunoreactivity score(IRS) was estimated.Results The IRS of TS in BTCC was(3.38?2.15).The IRS of TS protein in stage of T_(2-4) was significantly higher than that in stage of T_(a-1),and the IRS was elevated with the increase of pathological grade of BTCC(all P
