The influence of calcium channel blockers on intracellular calcium levels of cold preservation-reperfusion injury during liver transplantation in rats
- VernacularTitle:钙通道阻滞剂对大鼠肝移植冷保存再灌注损伤中细胞内钙的影响
- Author:
Hongtao LIU
;
Yongguo LI
- Publication Type:Journal Article
- Keywords:
Calcium channel blockers;
Liver transplantation;
Cryopreservation;
Reperfusion injury;
Calcium
- From:
Journal of Chinese Physician
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of calcium channel blockers on intracellular calcium levels of cold preservation-reperfusion injury during liver transplantation in rats.Methods According to the ingredient of perfusion and preservation solutions,the animals were divided into four groups: the control group with HCA solution,the experimental group I with HCA solution plus Verapamil,the experimental group II with HCA solution plus Nifedipine and experimental group III with HCA solution plus Diltiazem.The intracellular calcium of the rat hepatocytes and liver function were measured and the liver structure was observed under light and electron microscopy.Results There were significant differences between the experimental groups and the control group in intracellular calcium concentration and liver function(P
