Expression of protein kinase C in platelets and erythrocytes from older patients with coronary heart disease
- VernacularTitle:老年冠心病患者血小板及红细胞蛋白激酶C的表达
- Author:
Huimin CHEN
;
Hua GE
;
Xuan WANG
- Publication Type:Journal Article
- Keywords:
Protein kinase C;
Coronary disease;
Blood platelets;
Erythrocytes;
Myocardial infarction;
Angina,unstable
- From:
International Journal of Laboratory Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relation between protein kinase C(PKC) and coronary heart disease.Methods To measure the activity of PKC and its inhibitor(PKCI) in platelets,the activity of PKC in erythrocytes from 43 patients with unstable angina pectoris(UAP),45 patients with acute myocardial infarction (AMI),and 42 healthy controls(HC),respectively.Results The PKC activity in platelet membrane from UAP and AMI patients was higher than that from HC.The PKC activity in plalelet cytosol from UAP and AMI patients was lower than that from HC.The PKC activity in platelet cytosol from UAP patients was lower than that from AMI patients.The PKC activity in erythrocyte membrane from UAP and AMI patients was higher than that from HC.The PKC activity in erythrocytes cytosol from UAP and AMI patients was lower than that from HC.Conclusion PKC is likely to be associated with the pathogenesis of coronary heart disease.
