Analysis of metallo-beta-lactamase producing of strains resistant to imipipenem in pseudomonas aeruginosa
- VernacularTitle:耐亚胺培南铜绿假单胞菌产金属?-内酰胺酶的研究
- Author:
Peifen WANG
;
Juan ZHANG
;
Yuanchun HUANG
- Publication Type:Journal Article
- Keywords:
Pseudomonas aeruginosa;
Imipenem;
Beta-lactamases;
Metalloproteases;
Drug tolerance
- From:
International Journal of Laboratory Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the situation of metallo-beta-lactamase(MBL) producing of strains resistant to imipenem in pseudomonas aeruginosa(PA) isolated from hospital patients from April to July in 2005.Methods PA strains were isolated and antimicrobial resistances were done by the VITEK auto-microbic system.MBL producing strains were detected by Kirby-bauer method.Results 103 strains of PA were isolated. There were 47 strains resistant to imipenem and 16 strains resistant to ceftazidime. 8 strains were found MBL producing. Accounted for 17.0% of resistance strains to imipenem. One of 8 strains was sensitive to levofloxacin,others were resistant to such antibiotics as carbenicillin, amikacin, ticarcillin/clavulanic acid, cefoperazone, ceftazidime, cefepime, netilmicin, trimethoprim/sulfamethoxazole, piperacillin/tazobactam, ciprofloxacin. Non-MBL producing strains were found resistant to almost all antibiotics, except that 2 strains were sensitive to carbenicillin and one was sensitive to amikacin.Conclusion Among the PA strains isolated from clinic, both MBL producing strains and non-MBL ones were multiple antimicrobial resistance.It was one of the antimicrobial merchanisms that MBL producing led to PA resistant to cephalosporins and carbapenems. Antimicrobial agents should be chosen reasonably under the help of laboratory detecting this type correctly so as to reduce the antimicrobial resistance.
