Preparation and Quality Control of Compound Ofloxacin Gargle
- VernacularTitle:复方氧氟沙星含漱液的制备及质量控制
- Author:
Jingwen HUANG
;
Yin LI
- Publication Type:Journal Article
- Keywords:
Compound ofloxacin gargle;
Tinidazole;
Ofloxacin;
Content;
Stability
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare compound ofloxacin gargle,and to establish a method for its quality control.METHODS:Compound oflorxacin gargle was prepared with tinidazole,ofloxcin,heavy peppermint water,glycerol and puri-fied water.Differential spectrophotometry was employed to determine the content of tinidazole without isolation,and then the content of ofloxcin was calculated by formula on the basis of absorbability additivity principle.RESULTS:The prepared gargle was light green yellow clear liquid.The average recovery rates of tinidazole and ofloxacin were98.92%(RSD=0.35%)and99.18%(RSD=0.54%),respectively.No distinct decrease in content of these two components was found in3month test.CONCLUSION:The established method of preparation is simple,and that of content determination is convenient as well as that preparation is stable,which can be widely used in hospitals at primary level.
