Effect of Shenyankang(肾炎康) on levels of tumor necrosis factor-? and endothelin-1 in rats with mesangial proliferative glomerulonephritis
- VernacularTitle:肾炎康对系膜增生性肾炎大鼠肿瘤坏死因子-?和内皮素-1的影响
- Author:
Pijiang ZHU
;
Bing XIE
;
Liping JIANG
- Publication Type:Journal Article
- Keywords:
Shenyankang;
mesangial proliferative glomerulonephritis;
tumour necrosis factor-?;
endothelins
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the mechanism of Shenyankang(肾炎康) on rats with mesangial proliferative glomerulonephritis(MsPGN).Methods: MsPGN rat model was induced by chronic(serum-sickness).Six weeks later,MsPGN rats were given 3 ml of Shenyankang oral liquor every day(Shenyankang oral liquor treated group) or 3 ml of water every day(model group).Forty-two days after(using) the drug,urine protein(UP) of 24 hours,renal function and urine level of tumor necrosis factor?(TNF?) and endothelin1(ET1) were evaluated.Pathologic changes of renal tissue were observed by microscopy.Results: Compared to the normal control group,UP of 24 hours,blood urea nitrogen(BUN), serum creatinine(SCr) and urine level of TNF? and ET1 increased significantly in model group((all P
