Effect of salvia miltiorrhiza on mitochondria respiratory function of hepatic cells in rats with burn
- VernacularTitle:丹参对烧伤大鼠肝细胞线粒体呼吸功能的影响
- Author:
Zhenzhong QIU
;
Rui LI
;
Cairong QIU
;
Lijun MA
;
Leiqi GU
;
Jin TANG
- Publication Type:Journal Article
- Keywords:
burn;
salvia miltiorrhiza;
liver;
mitochondria;
oxygen free radical
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of salvia miltiorrhiza on mitochondria respiratory function of hepatic cells and oxygen radicals in rats with burn.Methods: Ninety-six Sprague-Dawley rats were randomly divided into normal control group,model group and salvia miltiorrhiza group.Rats in model group and salvia miltiorrhiza group were subjected to a 20% total body surface area(TBSA) full-thickness thermal injury.The levels of cytochrome aa3,cytochrome C,energy production and superoxide dismutase(SOD) in mitochondria of hepatic cells were dynamically determined at 1,2 and 6 hours after injury.Results: ①The levels of cytochrome aa3 in model group and salvia miltiorrhiza group did not change obviously within 2 hours after burn,while they were much lower than that in normal control group at 6 hours after burn,and the level of cytochrome aa3 in salvia miltiorrhiza group was obviously higher than that in model group(all P
