The correlation among connective tissue growth factor,transforming growth factor-? receptor,and extracellular matrix in human proliferative membranes of proliferative vitreoretinopathy
- VernacularTitle:增生性玻璃体视网膜病变增生膜中结缔组织生长因子与转化生长因子?受体和细胞外基质相关性的研究
- Author:
Changmei GUO
;
Yannian HUI
;
Yusheng WANG
- Publication Type:Journal Article
- Keywords:
Vitreoretinopathy,proliferative;
Connective tissue;
Growth substances;
Transforming growth factor beta;
Extracellular matrix;
Immunohistochemistry
- From:
Chinese Journal of Ocular Fundus Diseases
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).Statistical analysis showed that there was a correlation between the expression of CTGF and TGF-?RⅡ,FN,and collagen Ⅰ and Ⅲ protein,respectively. Conclusions The expression of CTGF and TGF-?RⅡ protein is up-regulated in PRM of PVR,which suggests that the activation of TGF-?RⅡ is involved in the production of CTGF,and CTGF is closely related to the production of ECM and play an important role in the pathogenesis of PVR.
