Effect of COX-2 and Ki- 67 expression and tumor microvessel density in primary gastric cancer tissue and clinicopathological parameters on postoperative gastric cancer recurrence
- VernacularTitle:胃癌组织中环氧合酶2、Ki-67、微血管密度及临床病理因素对胃癌复发的影响
- Author:
Yuming LI
;
Wenhua ZHAN
;
Yulong HE
;
Junsheng PENG
;
Fanghai HAN
;
Shirong CAI
;
Jinping MA
;
Gang ZHAO
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Recurrence;
Pathology, clinical
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between COX-2 and Ki-67 expression and microvessel density in primary gastric cancer tissue and clinicopathological parameters and to investigate their effect on postoperative gastric cancer recurrence. Methods Forty-eight postoperative recurrent gastric cancer patients were enrolled in this study, their clinicopathologic characters of primary tumors were analyzed retrospectively and compared with 48 cases without recurrence. Expression of COX-2 and Ki-67 and microvessel density ( MVD) in gastric cancer tissue were detected by immunohistochemical method. Risk factors correlated with tumor recurrence were studied by univariate and multivariate analysis. Results Expression of COX-2, Ki-67 label index (LI) and MVD were correlated with each other, and they were all correlated with depth of invasion and TNM stages in gastric cancer tissue. Patients with pelvic metastatic lymph node, cancer invasion to serosa, of Borrmann III or IV, high COX-2 and MVD expression are on high risk of recurrence (P
