The expression of VEGF-D and prognosis of patients with colorectal carcinoma
- VernacularTitle:大肠癌组织中血管内皮生长因子D表达与预后的关系
- Author:
Weiguo HU
;
Bo FENG
;
Junjun MA
;
Aiguo LU
;
Minghang WANG
;
Jianwen LI
;
Yanyan HU
;
Feng DONG
;
Zhihai MAO
;
Lu ZANG
;
Yu JIANG
;
Minhua ZHENG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Vascular endothelial factor-D;
Lymphangiogenesis;
Prognosis
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of vascular endothelial factor ( VEGF) -D in predicting the prognosis of colorectal carcinoma (CRC). Methods Between Jan 1996 and Jan 1998, 69 patients with CRC undergoing curative surgery were included in this study. Postoperative follow-up included physical examination, serum CEA, and imaging every 3 months in the first and the second year, every 6 months in the third year and once a year thereafter. The expression of VEGF-D protein and microvessel density ( MVD ) in 69 tissues of CRC and 20 normal colorectal tissues was examined by immunohistochemistry (IHC). Results of IHC staining were quantified by Axioplan 2 imaging analysis system. Results VEGF-D protein expression in the cytoplasm was found in all of the CRC tissues and 25% (5/20 ) of normal tissues. The VEGF-D expression was much higher in tumor tissue than in the corresponding normal tissue (P
